PKRRATING FOR DUMMIES

dPKR kinase area phosphorylated on residue T446 equivalent to chain B in the PKR kinase – eIF2α crystal composition PDB ID 2A19. 17 autophosphorylation at T466 will not be feasible During this geometry and also the docking site on helix αG for the substrate eIF2α is blocked. on the other hand, comparable interfaces employing the αEF and αG